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Docetaxel

Different acneiform rashes linked to EGFRI treatment

Docetaxel Accord - FASS Allmänhe

  1. Docetaxel är en substans som har sitt ursprung i barren från idegranen. Docetaxel hör till gruppen anti-cancerläkemedel som kallas taxoider. Din läkare har ordinerat Docetaxel Accord för behandling av bröstcancer, speciella former av lungcancer (icke-småcellig lungcancer), prostatacancer, magsäckscancer eller huvud- halscancer
  2. Docetaxel (DTX or DXL), sold under the brand name Taxotere among others, is a chemotherapy medication used to treat a number of types of cancer. This includes breast cancer, head and neck cancer, stomach cancer, prostate cancer and non-small-cell lung cancer. It may be used by itself or along with other chemotherapy medication. It is given by slow injection into a vein
  3. dre av cytostatika

Docetaxel - Wikipedi

Docetaxel side effects. You may have a life-threatening allergic reaction or a severe skin reaction. Get emergency medical help if you have signs of an allergic reaction: hives, burning eyes, skin pain, red or purple skin rash with blistering and peeling; fever, sore throat, wheezing, chest tightness, trouble breathing; feeling like you might pass out; swelling of your face, lips, tongue, or. Docetaxel injection final dilution for infusion, if stored between 2°C and 25°C (36°F and 77°F) is stable for 6 hours. Docetaxel injection final dilution for infusion (in either 0.9% Sodium Chloride solution or 5% Dextrose solution) should be used within 6 hours (including the 1 hour intravenous administration)

Triple-negative breast cancers with amplification of JAK2

  1. Docetaxel is approved to be used alone or with other drugs to treat: Breast cancer that is locally advanced or has metastasized (spread to other parts of the body) and has not gotten better with other chemotherapy. It is also used with doxorubicin hydrochloride and cyclophosphamide to treat breast cancer that is node-positive and can be removed.
  2. Docetaxel is an antineoplastic agent belonging to the taxane family. It is a semisynthetic preparation derived from the needles of yew plants. Its mechanism of action is similar to that of paclitaxel. Docetaxel is indicated for the treatment of locally advanced breast cancer, non-small cell lung, prostate, gastric, and head and neck cancers
  3. Docetaxel blocks the ability of cells to break down the internal 'skeleton' that allows them to divide. With the skeleton still in place, the cells cannot divide and they eventually die. Because docetaxel works on dividing cells, it also affects affects non-cancer cells such as blood cells, which can cause side effects
  4. För enkelhetens skull samlar jag här de biverkningar som drabbat mig under behandlingen med Docetaxel Actavis. Rekommendation: Se till att få recept på bra smärtstillande medicin inför Taxoteren! Jag fick Tramadol Stada, men det finns säkert andra lika bra. Panodil och liknande räcker inte långt här om man får smärta, vilket naturligtvis inte alla får
  5. aser (ALAT og/eller ASAT) >1,5 × ULN og samtidig forhøyet alkalisk fosfatase >2,5 × ULN, er anbefalt dose 75 mg/m 2.Ved forhøyet serumbilirubin og/eller ASAT og ALAT >3,5 × ULN og samtidig ALP >6 × ULN, kan dosereduksjon ikke.
  6. Docetaxel i kombination med trastuzumab har studerats för behandling av patienter med metastaserande bröstcancer vilkas tumörer överuttrycker HER2 och som tidigare inte fått kemoterapi mot metastaserande sjukdom. 186 patienter randomiserades för behandling med docetaxel (100 mg m2) med eller utan trastuzumab. 60 % av patienterna hade tidigare behandlats med antracyklinbaserad adjuvant.

Docetaxel Uses, Side Effects & Warnings - Drugs

Docetaxel is used to treat breast, prostate, stomach, head and neck and non-small cell lung cancer (NSCLC).. It may sometimes be used to treat other cancers. It is best to read this information with our general information about the type of cancer you have.. Your doctor will talk to you about this treatment and its possible side effects before you agree to have treatment Docetaxel (Taxotere) chemotherapy side effects, how it's given, how it works, precautions and self care tips for treatment of breast, lung, stomach, head and neck, and prostate cance Docetaxel can cause an allergic reaction. To try to prevent this, your doctor or nurse give you steroid tablets to take. You usually take them for 3 days, starting the day before each treatment. You can take steroids just a few hours before your treatment if you have prostate cancer Docetaxel (Bröst högdos, adjuvant till högriskpatienter) Inf Docetaxel 100 mg/m 2 Dag 1 Inj G-CSF 300 µg/30 ME till patienter < 70 kg 480 µg/48 ME till patienter > 70 kg Dag 4 -11 Endast inför kur 1: ASAT, ALAT, Bilirubin. Inför varje kur: Blodstatus, Neutr. Mellanprov: Blodstatus dag 9 (nadir). Före kur: Kortisonschema för högdos.

Taxandelen: docetaxel eller paklitaxel Behandlingen ges med tre cykler docetaxel, var tredje vecka intravenöst Tillägg av G-CSF (filgrastim eller pegfilgrastim ) rekommenderas som primär profylax p g a neutropeni med infektionsrisk Starkt vetenskapligt stöd för tidig behandling med docetaxel Det finns ett starkt vetenskapligt stöd för tidig behandling med docetaxel vid spridd prostatacancer. I internationella riktlinjer rekommenderas snar insättning av kastrationsbehandling och docetaxel, för de patienter som är i skick för detta, men i Sverige har varken docetaxel eller något annat cytostatikum den indikationen Docetaxel was clastogenic in the in vitro chromosome aberration test in CHO-K1 cells and in the in vivo micronucleus test in mice administered doses of 0.39 to 1.56 mg/kg (about 1/60th to 1/15th the recommended human dose on a mg/sq m basis). Docetaxel was not mutagenic in the Ames test or the CHO/HGPRT gene mutation assays Docetaxel ska ges när antalet neutrofila granulocyter är 1,5 x 109/l. Reducerad dos ska ges till patienter som får febril neutropeni, neutrofila granulocyter < 0,5 x 109/l i mer än en vecka, svåra eller kumulativa hudreaktioner eller svår perifer neutropati unde

Docetaxel is also a second-line treatment for patients with non-small cell lung cancer, prostrate cancer, gastric adenocarcinoma, and squamous cell carcinoma of the head and neck. Review side effects, drug interactions, dosage, and pregnancy safety information prior to receiving this medication Docetaxel is currently approved in the US for the treatment of head and neck cancer, gastric cancer, breast cancer, prostate cancer, and non-small cell lung cancer, and it is commercialized under the brand name Taxotere, by the pharmaceutical company Aventis Pharmaceuticals, Inc

Docetaxel has caused severe (rarely fatal) allergic reactions and swelling (fluid retention/edema) even with the use of preventive medications. This drug must not be used in patients who have. Docetaxel, a new taxoid family member originally derived from the needles of the European Yew tree Taxus baccata, is a potent chemotherapeutic agent that acts as a spindle poison to inhibit microtubule dynamics and cell cycle arrest through promoting microtublin assembly and stabilizing the polymers against depolymerization Docetaxel - Metastatic Castration-Resistant Prostate Cancer; Docetaxel - Non-Small Cell Lung Cancer (NSCLC) Docetaxel - Non-Small Cell Lung Cancer (Second or Subsequent Line

Histoire et principes d'action. Le docétaxel est un diterpène obtenu par hémisynthèse en 1989 à partir d'une molécule extraite des feuilles de l'if européen (Taxus baccata) à l'Institut de chimie des substances naturelles de Gif-sur-Yvette, alors dirigé par Pierre Potier, à qui sera décerné la médaille d'or du CNRS en 1998 [2].. Le docétaxel est un analogue du paclitaxel, de. Det finns ett starkt vetenskapligt stöd för tidig behandling med docetaxel vid spridd prostatacancer. I internationella riktlinjer rekommenderas snar insättning av kastrationsbehandling och docetaxel, för de patienter som är i skick för detta, men i Sverige har varken docetaxel eller något annat cytostatikum den indikationen

docetaxel: Taxotere Pharmacologic class: Mitosis inhibitor Therapeutic class: Antineoplastic Pregnancy risk category D FDA Box Warning • Give under supervision of physician experienced in cancer chemotherapy, in facility with adequate diagnostic and treatment resources. • Treatment-related death is more likely if patient has abnormal hepatic. Docetaxel ist ein Arzneimittel, das zur Therapie von Krebserkrankungen angewendet wird, da es über eine zytostatische Wirkung verfügt. 2 Chemie. Die chemische Summenformel von Docetaxel lautet: C 43 H 53 NO 14; Es handelt sich um einen weißen Feststoff mit einem Schmelzpunkt von 232 °C Patientinformation . om Taxotere ® (docetaxel) sanofi-aventis AB . Box 14142, 167 14 Bromma Tel 08-634 50 00. Fax 08-634 55 00 www.sanofi.se . Vid frågor om våra läkemedel kontakta: infoavd@sanofi.co Docetaxel Teva is used with cisplatin and 5-fluorouracil (other anticancer medicines); head and neck cancer in patients whose cancer is locally advanced (a cancer that has grown but has not spread). Docetaxel Teva is used with cisplatin and 5‑fluorouracil. The medicine can only be obtained with a prescription Beställ Docetaxel Actavis koncentrat till infusionsvätska, lösning 20 mg/ml hos Apoteket - Fraktfria alternativ och alla läkemedel i lager. Handla online eller i buti

Docetaxel - FDA prescribing information, side effects and use

Docetaxel is approximately 2 times as potent as paclitaxel and at least 5 times more potent against paclitaxel-resistant cells. 2. Although some reports indicate a cross-reactivity rate of 90% between docetaxel and paclitaxel, others suggest it does not occur consistently. 3,4. Docetaxel is cell cycle phase-specific for the G. 2 /M phase. 1, Ramaswamy and Puhalla (2006) Docetaxel: a tubulin-stabilizing agent approved for the management of several solid tumors. Drugs Today (Barc) 42 265 PMID: 16703123 If you know of a relevant reference for Docetaxel, please let us know Visit ChemicalBook To find more Docetaxel(114977-28-5) information like chemical properties,Structure,melting point,boiling point,density,molecular formula,molecular weight, physical properties,toxicity information,customs codes. You can also browse global suppliers,vendor,prices,Price,manufacturers of Docetaxel(114977-28-5). At last,Docetaxel(114977-28-5) safety, risk, hazard and MSDS, CAS. Docetaxel (INN) är ett väletablerat läkemedel med bevisad effekt mot tidig och långt framskriden prostatacancer. Oasmias micellära formulering av docetaxel ska förbättra doxetaxels löslighet och göra så att man inte behöver obligatorisk premedicinering med steroider, vilket anses skadligt för patienter i avancerat stadium med aktiv skelettcancer

Video: Docetaxel - National Cancer Institut

Docetaxel is used to treat primary breast cancer (cancer that has not spread beyond the breast or the lymph nodes under the arm) in combination with other chemotherapy drugs. Before surgery . Docetaxel can be given before surgery to shrink a larger breast cancer. This may mean breast-conserving surgery is an option, rather than a mastectomy Application Docetaxel can be used to study antibiotics, cell biology, cell signaling, neuroscience and apoptosis and the cell cycle. Docetaxel has been used to study the prevention of chemotherapy-induced alopecia, as well as the treatment of non-small-cell lung cancer in patients contraindicated for standard chemotherapy Results: Docetaxel promotes the assembly of and stabilizes microtubules, preventing their depolymerization. In phase I studies in patients with solid tumors refractory to standard chemotherapy, docetaxel's major dose-limiting toxicity (DLT) was dose- but not schedule-dependent neutropenia; another major side effect was schedule-dependent grade 3 mucositis Docetaxel for the treatment of hormone-refractory metastatic prostate cancer (June 2006) NICE TA101. Docetaxel is an option for hormone-refractory metastatic prostate cancer only if their Karnofsky score is at least 60% [Karnofsky score is a measure of the ability to perform ordinary tasks]

Docetaxel - an overview ScienceDirect Topic

Taxotere European Medicines Agenc

DEP® docetaxel Summary and Commercial Opportunity. Starpharma is developing an enhanced form of docetaxel known as DEP ® docetaxel (dendrimer-docetaxel).. Docetaxel is a leading chemotherapy drug used to treat a wide range of solid tumours including breast, lung and prostate Docetaxel is a semi-synthetic, second-generation taxane derived from a compound found in the European yew tree, Taxus baccata. Docetaxel displays potent and broad antineoplastic properties; it binds to and stabilizes tubulin, thereby inhibiting microtubule disassembly which results in cell- cycle arrest at the G2/M phase and cell death. This agent also inhibits pro-angiogenic factors such as.

Docetaxel(Taxotere), an analog of taxol, is an inhibitor of depolymerisation of microtubules through binding to stabilized microtubules. MedChem Express IC50 Value:; Target: Microtubule/Tubulin; in vitro: IC50 concentrations (reducing survival by 50%) ranged from 0.13-3.3 ng/ml, with three neuroblastoma lines proving most sensitive and three breast and two colon carcinoma lines showing least. Docetaxel injection may increase your risk of developing other cancers, such as blood or kidney cancer, several months or years after treatment. Your doctor will monitor you during and after your docetaxel treatment. Talk to your doctor about the risks of receiving this medication. Docetaxel injection may cause other side effects

Taxotere biverkningar Mitt enastående li

Docetaxel can cause your body to hold too much fluid, which can be a serious side effect. Medications will be given before each treatment to decrease the risk of this side effect. Call your healthcare provider if you do not urinate for more than 12 hours, experience shortness of breath, have an unexpected weight gain, or develop swelling in your hands, feet, ankles or legs Docetaxel (Taxotere®), a cytotoxic taxane, is an antimicrotubule agent effective in the treatment of patients with breast cancer. The clinical profile of docetaxel as an effective cytotoxic agent in the treatment of metastatic breast cancer is well established. As yet, no single standard regimen has been identified as optimal for the treatment of patients with metastatic breast cancer after.

Clinical trials are research studies that involve people. The clinical trials on this list are studying Docetaxel. All trials on the list are supported by NCI.. NCI's basic information about clinical trials explains the types and phases of trials and how they are carried out. Clinical trials look at new ways to prevent, detect, or treat disease Docetaxel Injection in combination with doxorubicin and cyclophosphamide is indicated for the adjuvant treatment of patients with operable node-positive breast cancer. 1.2 Non-Small Cell Lung Cancer . Docetaxel Injection as a single agent is indicated for the treatment of patients with locall Docetaxel Teva används endast då halten av neutrofiler (halten av en sorts vita blodkroppar) är normal (minst 1 500 celler/mm 3). Dexametason (ett antiinflammatoriskt läkemedel) ska också ges till patienten med start dagen före infusionen med Docetaxel Teva Docetaxel (Taxotere), a cytotoxic taxane, is an antimicrotubule agent effective in the treatment of patients with breast cancer. The clinical profile of docetaxel as an effective cytotoxic agent in the treatment of metastatic breast cancer is well established. As yet, no single standard regimen has

Docetaxel Accord «Accord» - Felleskataloge

Docetaxel is a white to almost-white powder with an empirical formula of C 43 H 53 NO 14, and a molecular weight of 807.88. It is highly lipophilic and practically insoluble in water. Docetaxel Injection, USP is a sterile, non-pyrogenic, clear, colorless to pale yellow solution at 10 mg/mL concentration Searches without any special characters (listed below) will return items that contain the exact value(s) entered in the search field Docetaxel 80mg/4ml concentrate for solution for infusion vials (Fresenius Kabi Ltd) Active ingredients Size Unit NHS indicative price Drug tariff Drug tariff price; Docetaxel 20 mg per 1 ml; 1: vial (POM) £710.26 (Hospital only. docetaxel. docetaxel: translation. n. a taxane used in the treatment of breast cancer, advanced or metastatic non-small-cell lung cancer. docetaxel: translation. noun. A particular drug used in chemotherapy. Wikipedia foundation. intelligence; nonastronomer; Look at other dictionaries: Docétaxel — structure Général No CAS Wikipédia en Français

Find here huge list of docetaxel (cas no 114977-28-5), docetaxel manufacturers, docetaxel suppliers, docetaxel exporters along with docetaxel manufacturing companies from India DOCETAXEL is a chemotherapy drug. It targets fast dividing cells, like cancer cells, and causes these cells to die. This medicine is used to treat many types of cancers like breast cancer, certain stomach cancers, head and neck cancer, lung cancer, and prostate cancer Docetaxel Amring 20 mg/ml koncentrat till infusionsvätska, lösning docetaxel Läs noga igenom denna bipacksedel innan du börjar använda detta läkemedel. Den innehåller information som är viktig för dig. Spara denna information, du kan behöva läsa den igen Finally, the docetaxel group had a higher 6-year disease-free survival (DFS) rate of 65% compared with 55% in AS + RT (HR, 0.76; 95% CI, 0.58-0.99; two-sided P =.043). This study had a median.

DOCETAXEL INJECTION. This product information is intended only for residents of the United States. for Health Care Professionals: DOCETAXEL, 10 mg/1 mL Vial - Hospira U.S. Physician Prescribing Information; DOCETAXEL, 20 mg/1 mL Vial, U.S. Physician Prescribing Information; See related articles Docetaxel (Taxotere®), a semi-synthetic analog of paclitaxel (Taxol®), is a promoter of microtubule polymerization leading to cell cycle arrest at G2/M, apoptosis and cytotoxicity. Docetaxel has significant activity in breast, non-small-cell lung, ovarian and head and neck cancers. Docetaxel has undergone phase I study in a number of schedules, including different infusion durations and.

Docetaxel Actavis, Koncentrat till infusionsvätska

Docetaxel will be banded as per the CSCCN agreed bands. Docetaxel induced fluid retention can lead to weight gain. This is not a reason to alter the doses Docetaxel doses of more than 200mg should be diluted in 500ml sodium chloride 0.9% (maximum concentration .74mg/ml) Prednisolone is available as 5mg (uncoated) and 2.5mg and 5mg (enteric coated Docetaxel may interact with strong CYP3A4 inhibitors (e.g. ketoconazole) and proteosome inhibitors (e.g. Ritonavir) may increase concentrations of docetaxel and lead to increased toxicity or side effects. More frequent laboratory monitoring and docetaxel dosage adjustment may be needed; Severe hypersensitivity may occur, although rar Docetaxel is a prescription chemotherapy drug used to treat different kinds of cancer, including cancers of the breast, prostate, stomach, head and neck cancers, and non-small-cell lung cancer BackgroundAndrogen-deprivation therapy (ADT) has been the backbone of treatment for metastatic prostate cancer since the 1940s. We assessed whether concomitant treatment with ADT plus docetaxel wou..

HER2+ Disease in the Adjuvant and Metastatic Setting

{{configCtrl2.info.metaDescription} Docetaxel final dilution for infusion, if stored between 2°C and 25°C (36°F and 77°F) is stable for 6 hours. Docetaxel final dilution for infusion (in either 0.9% Sodium Chloride solution or 5% Dextrose solution) should be used within 6 hours (including the 1 hour intravenous administration) Docetaxel plus nintedanib showed similar efficacy to docetaxel plus ramucirumab in the nonsquamous populations. EGFR tyrosine kinase inhibitors (TKIs) erlotinib and gefitinib showed superior levels of efficacy in EGFR mutation-positive populations and the one PD-1 immunotherapy (nivolumab) studied showed superior efficacy in the populations exhibiting high PD-L1 expression Taxotere (docetaxel) works similarly to many chemotherapy medications by disrupting cell division (called mitosis). Since cancer cells are some of the most rapidly dividing cells in the body, these cells are preferentially affected by the action of Taxotere and, consequently, die at high rates when the drug is administered

Cystoid macular edema associated with chemotherapy | CMAJMees lines and Beau lines after chemotherapy | CMAJ

Biverkningar av Docetaxel Actavis På Fass.se. Här kan du läsa mer om biverkningar av Docetaxel Actavis samt övrig information på Fass.se Av Docetaxel kan du bland annat uppleva illamående, diarré, håravfall, rodnad och svullnad i handflator och under fotsulor, svullnad av händer, fötter eller ben, viktökning, viktminskning, domningskänsla, trötthet, aptitlöshet och nagelförändringar. Vid misstanke om omfattande och/eller oacceptabla biverkningar bör du kontakta di Looking for online definition of Docetaxel or what Docetaxel stands for? Docetaxel is listed in the World's largest and most authoritative dictionary database of abbreviations and acronyms The Free Dictionar Medical definition of docetaxel: a semisynthetic antineoplastic drug C43H53NO14·3H2O that is administered intravenously to treat various cancers (as of the lung, breast, or prostate) and is derived from the needles of a yew tree (Taxus baccata) of Europe

Docetaxel - Macmillan Cancer Suppor

Docetaxel in combination with doxorubicin and cyclophosphamide: adjuvant therapy. Patients with operable node-positive breast cancer (TAX 316) Data from a multicenter open label randomized study support the use of docetaxel for the adjuvant treatment of patients with operable node-positive breast cancer and KPS ≥ 80%, between 18 and 70 years. Brand name: Taxotere Chemical name: Docetaxel Class: Taxane chemotherapy.Abraxane and Taxol are other taxanes.. How it works: Taxanes interfere with the ability of cancer cells to divide. Uses: Taxotere usually is given in combination with other chemotherapy medicines and is used after surgery to treat: advanced-stage breast cancer that isn't responding to doxorubici

Additives - Fresenius Kabi Egypt

Docetaxel - Drug Information - Chemocar

Docetaxel has a similar set of clinical uses to paclitaxel, and it is marketed under the brand name Taxotere. Taxanes, including paclitaxel, 10-deacetylbaccatin III, baccatin III, paclitaxel C, and 7-epipaclitaxel, have been found in the leaves and shells of hazel Docetaxel was approved by the U.S. Food and Drug Administration (FDA) in 2004, and it is commercialized under the brand name Taxotere by Aventis Pharmaceuticals. The injectable drug is indicated for the adjuvant treatment of women with operable node-positive breast cancer in combination with the drugs doxorubicin and cyclophosphamide

Targeting KRAS-Mutant Non–Small Cell Lung Cancer with theWith My Breast Cancer, My Doctor Was Wrong and My

Docetaxel (Taxotere) Cancer information Cancer Research U

Docetaxel 114977-28-5 Suppliers,provide Docetaxel 114977-28-5 product and the products related with China (Mainland) Docetaxel 114977-28-5 Shochem(Shanghai) Co., Ltd China (Mainland Docetaxel 114977-28-5 Suppliers,provide Docetaxel 114977-28-5 product and the products related with United States Docetaxel 114977-28-5 Aozeal Certified Standards, Inc United State Docetaxel Kabi - Information, Om, Hjälp - docetaxel - L01CD02 - Fresenius Kabi Oncology Pl

Bröstcancer, primärbehandling - Internetmedici

Läkemedelsfakta | Läkemedelsverket / Swedish Medical. Docetaxel Teva Pharma - Information, Om, Hjälp - docetaxel - L01CD02 - Teva Pharma B.V Docetaxel Hospira is for intravenous use only. The use of docetaxel should be confined to units specialised in the administration of cytotoxic chemotherapy and it should only be administered under the supervision of a physician qualified in the use of anticancer chemotherapy (see section 6.6) Nanoformulated docetaxel also outperformed conventional docetaxel in a patient-derived xenograft (PDX) model, doubling the extent of tumor growth inhibition. Furthermore, micellar docetaxel modulated the tumor immune microenvironment in CDX and PDX tumors, increasing the ratio between M1-and M2-like macrophages, and toxicologically, it was found to be very well-tolerated Docetaxel 114977-28-5 Suppliers,provide Docetaxel 114977-28-5 product and the products related with China (Mainland) Docetaxel 114977-28-5 Senova Technology Company Limited China (Mainland

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Help coping with Docetaxel/Taxotere. Please. 9 Sep 2013 09:22. Hi. I was diagnosed with grade 3 breast cancer in may. A swift and successful op was followed by FEC-T chemo. I've had all three FEC sessions and coped really well and was positive and active during docetaxel pressure to hands and feet, such as that treatment. The palms of your hands and soles of your feet may tingle, become red, numb, painful, or swollen. Skin may also become dry or itchy. You may not be able to do your normal daily activities if blisters, severe pain, or ulcers occur. •Avoid tight-fitting shoes or rubbin Side Effects. Drug information provided by: IBM Micromedex Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention Docetaxel(Taxotere) generic is an anti-cancer agent, mainly used for the treatment of breast, ovarian, gastric cancer, head and neck cancer, prostate cancer and non-small cell lung cancer either.

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